Deep Learning Modeling of Androgen Receptor Responses to Prostate Cancer Therapies
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منابع مشابه
Home > Expanding Androgen- and Androgen Receptor Signaling–Directed Therapies for Castration-Resistant Prostate Cancer Expanding Androgen- and Androgen Receptor Signaling– Directed Therapies for Castration-Resistant Prostate Cancer
Since the discovery by Huggins and Hodges in 1941 that prostate cancer is an androgen-dependent disease,[2] the mainstay of therapy for advanced disease has been androgen deprivation therapy (ADT). Unfortunately, after a variable period of time on ADT, patients eventually progress to the lethal form of prostate cancer in the setting of castrate levels of testosterone. During the past several ye...
متن کاملAndrogen receptor and prostate cancer
Androgens play a key role in the development and progression of prostate cancer, and androgen deprivation therapy (ADT) is the first line treatment for advanced disease. Although ADT is initially successful in controlling prostate cancer, many patients eventually become resistant to therapy and progress to develop lethal castration-resistant prostate cancer (CRPC). Androgens drive prostate canc...
متن کاملAndrogen receptor in prostate cancer.
The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). AR remains important in the development and progression of prostate cancer. AR expression is maintained throughout prostate cancer progression, and the majority of androgen-independent or hormone refractory prostate cancers express AR. Mutation of AR, especially mutations t...
متن کاملDiscovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpression as well as point mutations of AR. We report here the pharmacological profile of ODM-201, a nov...
متن کاملCost-effectiveness of androgen suppression therapies in advanced prostate cancer.
BACKGROUND The costs and side effects of several antiandrogen therapies for advanced prostate cancer differ substantially. We estimated the cost-effectiveness of antiandrogen therapies for advanced prostate cancer. METHODS We performed a cost-effectiveness analysis using a Markov model based on a formal meta-analysis and literature review. The base case was assumed to be a 65-year-old man wit...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21165847